Multisensory neurons throughout the neuraxis play an active role in transforming their different sensory inputs into an integrated output. These neurons have been shown to synthesize their inputs based on the spatial and temporal relationships of the combined stimuli, as well as on their relative effectiveness. Although these integrative principles have been extraordinarily useful as a foundation with which to assess the combinatorial operations carried out by multisensory neurons, they provide only a first-order approximation as to the results of any given multisensory combination. Although it has long been noted that the receptive fields of multisensory neurons are typically large and heterogeneous, the impact of receptive field architecture and the temporal dynamics of the evoked response on multisensory interactions has not been systematically evaluated. In the current study, we examined this issue by detailing the unisensory (i.e., visual, auditory) and multisensory (visual-auditory) spatial (SRFs) and spatiotemporal receptive fields (STRFs) of multisensory neurons in the cat anterior ectosylvian sulcus (AES) and superior colliculus (SC). In both structures, SRFs and STRFs revealed a strong interdependency between space, time and effectiveness in dictating the resultant interaction, and which provides a more dynamic description of the integrative profile of multisensory neurons.