We report a series of experiments designed to assess the influence of multisensory integration (MI) on the exogenous orienting of spatial attention. In Experiment 1, we compared the exogenous orienting elicited by auditory, visual, and audiovisual (bimodal) spatially-nonpredictive cues, while in Experiment 2, we used auditory, tactile, and audiotactile spatially-nonpredictive cues. In both experiments, participants had to discriminate the elevation (up/down) of visual targets preceded by either unimodal or bimodal cues under conditions of high perceptual load (in which they had to monitor a rapidly-presented central stream of visual letters for occasionally-presented target digits) or else no perceptual load (in which the central stream was replaced by a fixation point). The results of both experiments showed that all cues captured spatial attention in the no-load condition. By contrast, only the bimodal cues (i.e., audiovisual cues in Experiment 1, and audiotactile cues in Experiment 2) captured spatial attention in the high-load condition. The results of a third experiment demonstrated that the auditory and tactile cues need to be presented from the same direction in order for them to capture people’s attention effectively. These results therefore suggest that MI facilitates the disengagement of spatial attention from a concurrent perceptually-demanding stimulus, thus playing a crucial role in the exogenous orienting of spatial attention. The application of these results to the design of multisensory collision avoidance warning signals for drivers will also be highlighted.