The multisensory peripersonal space develops in a maturational process that is thought to be influenced by early sensory experience. We investigated the role of vision in the effective development of audiotactile interactions in the peripersonal space. Early blind (EB), late blind (LB) and sighted control (SC) participants were asked to lateralize auditory, tactile and audiotactile stimuli. The experiment was conducted with the hands uncrossed or crossed over the body midline. First, we observed that the crossed posture had detrimental effects on the processing of all stimuli types in SC and LB. In EB however, crossing the hands did not significantly impair tactile stimulus processing. Second, we demonstrate that improved reaction times observed in the bimodal conditions in SC and LB are related to nonlinear neural summation in both conditions of postures, indicating neural integration of different sensory information. In EB, nonlinear summation was obtained in the uncrossed but not in the crossed posture. We argue that the absence of a detrimental “crossed-posture effect� for tactile processing in EB is attributable to a lack of automatic external remapping of touch and proprioception. Such default use of an anatomically anchored reference system in EB prevents effective audiotactile interactions in the crossed posture due to the poorly aligned spatial coordinates of these two modalities in such condition. These results provide compelling evidence for the critical role of early vision in the development of the multisensory peripersonal space.